Tue, Jun 18, 2024
Whatsapp

Research explores how sleep helps in processing emotions

Written by  Shefali Kohli -- May 14th 2022 03:04 PM
Research explores how sleep helps in processing emotions

Research explores how sleep helps in processing emotions

Washington [US], May 13: Researchers at the Department of Neurology of the University of Bern and University Hospital Bern identified how the brain triages emotions during dream sleep to consolidate the storage of positive emotions while dampening the consolidation of negative ones. The work expands the importance of sleep-in mental health and opens new ways of therapeutic strategies. Role of sleep in emotional process Also Read: Obesity in pregnancy increases risk of heart disease in offspring, says study Rapid eye movement (REM or paradoxical) sleep is a unique and mysterious sleep state during which most of the dreams occur together with intense emotional content. How and why these emotions are reactivated is unclear. The prefrontal cortex integrates many of these emotions during wakefulness but appears paradoxically quiescent during REM sleep. In humans, excessively negative emotions, such as fear reactions and states of anxiety, lead to pathological states like Post-Traumatic Stress Disorders (PTSD). In Europe, roughly 15 per cent of the population is affected by persistent anxiety and severe mental illness. The research group headed by Antoine Adamantidis is now providing insights into how the brain helps to reinforce positive emotions and weaken strongly negative or traumatic emotions during REM sleep. A Dual mechanism Neurons are composed of a cell body (soma) that integrates information coming from the dendrites (inputs) and send signals to other neurons via their axons (outputs). The results obtained showed that cell somas are kept silent while their dendrites are activated. "This means a decoupling of the two cellular compartments, in other words, soma wide asleep and dendrites wide awake", explains Adamantidis. This decoupling is important because the strong activity of the dendrites allows the encoding of both danger and safety emotions, while the inhibitions of the soma completely block the output of the circuit during REM sleep. In other words, the brain favours the discrimination of safety versus danger in the dendrites, but blocks the over-reaction to emotion, in particular danger. Role of sleep in emotional process  A survival advantage According to the researchers, the coexistence of both mechanisms is beneficial to the stability and survival of the organisms: "This bi-directional mechanism is essential to optimize the discrimination between dangerous and safe signals", says Mattia Aime from the DBMR, first author of the study. If this discrimination is missing in humans and excessive fear reactions are generated, this can lead to anxiety disorders. The findings are particularly relevant to pathological conditions such as post-traumatic stress disorders, in which trauma is over-consolidated in the prefrontal cortex, day after day during sleep. Role of sleep in emotional process Also Read: 9 amazing uses of cinnamon for your mind, body and wardrobe Breakthrough for sleep medicine These findings pave the way to a better understanding of the processing of emotions during sleep in humans and open new perspectives for therapeutic targets to treat maladaptive processing of traumatic memories, such as Post Traumatic Stress Disorders (PTSD) and their early sleep-dependent consolidation. Additional acute or chronic mental health issues that may implicate this somatodendritic decoupling during sleep include acute and chronic stress, anxiety, depression, panic, or even anhedonia, the inability to feel pleasure. Sleep research and sleep medicine have long been a research focus of the University of Bern and the Inselspital, Bern University Hospital. "We hope that our findings will not only be of interest to the patients but also to the broad public", says Adamantidis. -PTC News  


Top News view more...

Latest News view more...

PTC NETWORK