This is how a common painkiller Paracetamol leads to serious liver damage: Study

Health and Fitness | Paracetamol, also known as acetaminophen, is a commonly used medication for relieving pain and reducing fever and is widely available over-the-counter and is often used to alleviate symptoms associated with headaches, muscle aches, menstrual cramps, toothaches, and colds can lead to serious liver damage if taken in excessive amount. 

The significant risk of acute liver failure associated with paracetamol (also known as acetaminophen) overdose. 

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A recent study conducted by a team at the University of Edinburgh examined the effects of paracetamol on mice, concluding that it can cause harm to living organisms. 

According to the researchers, these findings inform future investigations into therapies aimed at mitigating the adverse effects of the medication.

The study highlighted concerns regarding potential severe side effects for individuals who consume excessive amounts of paracetamol. Typically, patients with persistent pain are advised to limit their paracetamol intake to four grams per day.

Organ Failure

Paracetamol can result in acute liver failure, a life-threatening condition that requires urgent medical attention. Symptoms of liver failure include jaundice, abdominal pain, nausea, vomiting, and confusion.

The research, which focused on the impact of paracetamol on liver cells in both human and mouse tissue, revealed that in some specific conditions, paracetamol can harm the liver by disrupting the structural connections crucial for the normal functioning of adjacent liver cells.

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Additional Testing 

The researchers' next objective is to devise a dependable approach for utilizing human liver cells instead of animals for testing purposes. They plan to investigate the impact of various doses and durations of paracetamol on liver toxicity and pinpoint potential targets for novel medications. 

The study, published in Scientific Reports, involved collaboration among researchers from the Scottish National Blood Transfusion Service and the Universities of Edinburgh and Oslo. Partial funding for the study was provided by the Chief Scientist Office and the Biotechnology and Biological Sciences Research Council.

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It is important to note that the risk of liver damage from paracetamol overdose is higher in individuals with pre-existing liver conditions, such as hepatitis or cirrhosis, as well as those who consume alcohol regularly.

(With inputs from agencies)

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